Cabozantinib (Cometriq, Cabometyx) tablet Online | Apple pharmaceuticals

DESCRIPTION

Cabozantinib which is a type of targeted therapy drug used to recover from medullary thyroid cancer and kidney cancer that has spread. Its label contains a black box warning of gastrointestinal perforations, fistulas, and hemorrhage.
Cabozantinib is a prescription drug which is used under the supervision of doctors

INDICATION

Cabozantinib is used for the treatment of metastatic medullary thyroid cancer and for the treatment of patients having advanced renal cell carcinoma (RCC) who have to get before anti-angiogenic therapy.

MECHANISM

Cabozantinib is also called a tyrosine kinase inhibitor (targeted therapy drug). It works by prohibiting the signals inside cancer cells which made them grow and multiply. This may help to block or reduced the growth of cancer. It can also prohibit new blood vessels growing in cancer. Cancer cells require to make new blood vessels so they can develop and spread.

DOSAGE MODIFICATION

Avoid substitute Cabozantinib tablets with Cabozantinib capsules.
The prescribed dose of Cabozantinib is 60 mg.
Administration Cabozantinib is without food.
Advise the patients not to eat for at least 2 hours before and 1 hour after taking Cabozantinib. Follow the treatment until the patient no longer experiences clinical benefit or experiences unacceptable toxicity.
Swallow Cabozantinib tablets whole. Do not crush Cabozantinib tablets.

SIDE EFFECTS

• Thrombotic events
• Hypertension and hypertensive crisis
• Diarrhea
• Palmar-plantar erythrodysesthesia
• Reversible posterior leukoencephalopathy syndrome
• Hemorrhage
• GI perforations and fistulas

PRECAUTION

Monitor the patients for symptoms of perforations and fistulas contain abscess. stop Cabozantinib in patients who experience a perforation or a fistula.
Do not administer Cabozantinib to patients with a present history of hemorrhage or hemoptysis.
Discontinue the Cabozantinib in patients who develop an acute myocardial infarction, cerebral infarction, or any other clinically significant arterial thromboembolic complication.


DRUG INTERACTION

Cabozantinib concomitant use with strong CYP3A4 inhibitor will increase the single dose plasma Cabozantinib exposure by 38%.
Cabozantinib concomitant use with strong CYP3A4 inducers will decrease the single dose plasma Cabozantinib exposure by 77% .
Cabozantinib Combination with MRP2 inhibitors may increase the exposure to Cabozantinib

CONTRAINDICATION

Cabozantinib has contraindicated patients having a hypersensitivity reaction to the active substance or its excipients.

MISSED DOSE

If the patient vomits after taking a dose of Cabozantinib or missed to take a dose, they should not take an extra dose, but to take the next dose at the regular time, skip the missed dose. Do not take the missed dose within 12 hours of the next dose.

STORAGE

Store the drug at 20° to 25°
Keep away from the children resistances

FOR MORE INFORMATION:


EMAIL:


applepharmaceutical@gmail.com


PHONE:


91- 9987711567


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