BORTENAT 2MG INJECTION ( NATCO )

DESCRIPTION 

Bortezomib is a drug sold under the brand name of Bortenat 2mg which belongs to anti-neoplastic medicine, the main ingredient which is used as bortenat, which is available in the form of lyophilized powder Bortenat 2mg is a prime benign proteasome inhibitor; proteasome is a biological structure that clefts the proteins Pharmacological grouped as anti-neoplastic agent or proteasome inhibitor The drug is a prescription drug given under the supervision of pharmacist

INDICATIONS

Bortenat 2mg is majorly indicated for the treatment for patients suffering from the following disease. Multiple myeloma Mantle cell lymphoma

MECHANISM OF ACTION

The drug Bortenat is a type of chymotrypsin-like activity which is in the form of unstable prohibition of the 26S proteasome in human cells. The 26S proteasome is a group of protein that reduces the agglutinated proteins The various proteins are weakened by proteasome enzymes that make difficult to tumor cells persistence like cyclins, tumor suppressors, BCL-2 & cyclin-dependent kinase inhibitors The functioning site of proteasome has Postglutamyl peptide hydrolysis activity Chymotrypsin like Trypsin like Prevention of these degenerations, sensitizes cells to apoptosis and cell arrest and leads to cell lysis

DOSAGE

In adults: 

Multiple myeloma: 

Previously untreated multiple myeloma In the therapy: Bortenat dose 1.3mg/m2 should be given as 3 to 5 seconds via IV bolus or subcutaneous by interacting with tablet melphalan and prednisolone for nine 6 weeks treatment cycles Bortenat is taken for two times weekly, (day 1, 4, 8, 11, 22, 25, 29 and 32) for Cycles 1 over 4 Bortenat is taken once a week (day 1, 8, 22, and 29) for Cycles 5 over 9 Duration of Bortenat is 72 hours

In Relapse stage: 

The usual dose of Bortenat is 1.3mg/m2 should be given via IV bolus or subcutaneous as two times for two weeks (day1, 4, 8, and 11) followed by a ten day rest course (day 12 through 21) Schedule of Treatment increased above 8 cycles may be taken once weekly for 4 weeks (day 1, 8, 15, and 22), followed by 13 day rest (day 23 over 35)

Important points: 

Bortenat administrated alone or combined with dexamethasone therapy cycle require of Three-week course

SIDE EFFECTS

Most common side effects occurred after administration of Bortenat 2mg includes:

Burning, crawling, itching, numbness, prickling, Chest pain, Black tarry stools, Bleeding gums, Blood in urine, Blurred vision, Body aches, dizziness, faintness, nerve pain, painful urination, pale skin, runny nose, sore throat, stuffy nose, swollen glands, sunken eyes, ulcer, dry mouth, Cough producing mucus, ear congestion, loss of voice.

DRUG INTERACTION

Avoid interaction with st. Johns wort to decrease the exposure of Bortenat 2mg while concomitant with CYP3A4 inhibitors: there is a chance of getting Bortenat 2mg toxicity; so to reduce the dose of Bortenat 2mg Interaction with Strong CYP3A4 inducers: decrease the exposure of Bortenat 2mg while concomitant with melphalan-prednisone or dexamethasone alone No clinical effect on Bortenat 2mg exposure.

CONTRAINDICATION

Bortenat 2mg is administered through IV bolus or subcutaneous; whereas intrathecal administration is contraindicated to the patients who are receiving Bortezomib Hypersensitivity reaction occurs in patients who are contraindicated to Bortenat 2mg, boron, boric acid or glycine

PREGNANCY & LACTATION

Bortenat 2mg is not recommended in pregnancy condition. Bortenat 2mg causes fetal harm and leads to some adverse effect Breastfeeding is not recommended

STORAGE

Bortenat 2mg vial should be stored at 20° to 25° (68° to 77°); excursion between 15° to 30° (59° to 86°) Keep away from light and heat.

FOR MORE INFORMATION:


EMAIL:


applepharmaceutical@gmail.com

PHONE:


91- 9987711567


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