Rolimus 5mg tablet - Everolimus | Myapplepharma

DESCRIPTION

Rolimus 5mg belongs to a class of anti-cancer drugs
Rolimus 5mg contains an active compound known as Everolimus which interferes with the development of cancer cell and the process is slowed down.
Rolimus 5mg tablets is not a curable medication, which helps to slow their spreading into the body.

PRESCRIBED FOR

The drug Rolimus 5mg is mainly used for the treatment of the following disease
• kidney carcinoma
• Breast carcinoma
• Brain carcinoma
Rolimus 5mg is also used to treat in various advanced stage cancer in stomach, intestines or pancreas.

MECHANISM

Everolimus is a prohibition of mTOR, links at peak compatibility to FK506 binding protein 12, through producing drug complex which prevents the productive of mTOR. This inhibition reduces the activity of effectors downstream, which may lead to stoppage of cell progression from G1 into S phase, finally causes cell growth arrest and apoptosis. Rolimus also prohibits the expression of hypoxia-inducible factor, causing to a reduces in the expression of vascular endothelial growth factor. The result of everolimus prevention of mTOR is a reduction in cell multiplication, angiogenesis, and glucose uptake.

DOSAGE

Rolimus 5mg tablets should be given with or without food.
Dosage regimen of Rolimus:
In breast cancer, renal cell cancer, pancreatic cancer, Neuroendocrine cancer
The prescribed dosage is 10mg should be taken as a single dose. In Brain or intracranial cancer
The prescribed dosage of Rolimus as a single dose. is 4.5mg/m2 given orally
In pediatric:
The pediatric dosage of Rolimus as a single dose in brain or intracranial tumor is 4.5mg/m2 should be given orally.

SIDE EFFECTS

• Nephrotoxicity
• Thrombocytopenia
• Hypersensitivity reactions
• Hyperlipemia
• Angioedema
• Lymphomas & other malignancy
• Male infertility

DRUG-DRUG INTERACTION

Interaction of Rolimus 5mg with strong inhibitor of CYP3A4, or P-gp, cause reducing the efflux of Everolimus and high plasma concentration of Everolimus.
Concomitant use of Rolimus 5mg with strong CYP3A4 inducers will be increasing the disclosure of Everolimus.
Interaction of Rolimus 5mg with cyclosporine will be increasing the AUC level of Everolimus frequently. Interaction of ketoconazole with Rolimus 5mg tablet or other CYP3A4 inhibitors will increase the plasma concentration and AUC of Everolimus.

PREGNANCY

Pregnancy category of Everolimus C: In patients, Rolimus 5mg is used only after knowing the benefits to the mother exceed the risk to the fetus.

LACTATION

Breastfeeding should not be suggested

STORAGE

Rolimus 5mg tablet store at 25°C
Protect the medicine away from moisture, heat, and light.

MISSED DOSE

If the patients missed the dose, patients must consult with the medical practitioner and follow the instructions given by them. Or missed dose should be avoided and follow the regular dosing schedule.

FOR MORE INFORMATION:


EMAIL:


applepharmaceutical@gmail.com

PHONE:


91- 9987711567

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